Journal of Business Ethics Essay Example | Topics and Well Written Essays - 250 words

Journal of Business Ethics - Essay Example Some argue there is little evidence that the UNGC vision, an economy with the human face, can be realized for the poor and developing nations with economic globalization. Many do not agree with the assumption of the Global Compact that globalization in its current form can be made sustainable and equitable, even if accompanied by the implementation of standards for human rights, labour, and the environment because they are well aware that many corporations would like nothing better than to wrap themselves in the flag of UN in order to blue wash their public image. Williams argues that they should respond to any criticism of their practices and discuss corrective action where necessary. As indicated â€Å"We expose the reality in a field too often dominated by rhetoric and help protect vulnerable people and communities against abuses†. The second group of critics is not focusing so much on the mission of UNGC but rather on the fact that the initiative is housed in the UN. There were fears that businesses would become too dominant in the organization. Williams responds that the background of this criticism is important because the UN had no close relationship with the private sector and in the 1960s this was amplified as many developing countries moved away from their colonial masters and became independent, As indicated â€Å"The UN served as a countervailing power for developing countries who understood multinational companies to be partially responsible for their slow economic and human development†.

Intention Recklessness Case Study Example | Topics and Well Written Essays - 1000 words

Intention Recklessness - Case Study Example Intentionality in this case would depend largely upon the chance of death that Fabio was inflicting upon Alessandro. By the time the fourth bullet was in the gun Alessandro was more likely than not to kill himself with the next pull of the trigger. On the shot that actually killed him there was an 83.3% chance of Alessandro dying. Fabio committed an act that was likely to kill Alessandro. The fact that Alessandro "agreed" to the use of live bullets is irrelevant as a "reasonable man" would have known that the magician would have thought his manager was joking. The act of changing the black bullets for live ones was the equivalent of tying Alessandro up and loading a gun with one bullet, firing it, loading it with another etc. Fabio could be rationally charged (and would probably be convicted) of the intentional murder of Alessandro as he clearly had the mens rea through the use of live bullets and the actual swapping of the blanks for the real bullets was the actus reus (Simester, 2004). He had the oblique intent to kill him if not the specific intent. This case can be analyzed in three different stages. ... A reasonable person should know that such an active would be likely to cause harm to someone if they were hit by the car. The fact that schizophrenia could have the effect of depriving a person of the ability to know the inherent risk of what he was doing begs the question of whether it did in this case. Part of Toby's statement in court, "he hadn't though about he risk of hurting anyone" would suggest that the mental disease did indeed diminish his capacity but the subsequent comment "that he didn't really care" would suggest that he had at least a sense of "right and wrong". If a person states that they do not care about something there is the implication that they understand they should care. But this is Toby's state of mind in court, not at the time of the alleged offense. As he is a schizophrenic and as the court has accepted that this condition could cause him not to appreciate the risks involved with what he was doing, it seems that Toby did not recklessly cause Judy's injuries. There is sufficient doubt as to whether he could form the mens rea necessary at the time of the accident. Question 3 The fact that the Lords have attempted to give a satisfactory definition of "intention" on many occasions, the latest of which occurred in Woolin (1999) AC 82 HL does not necessarily render Williams' statement re. the impossibility of defining intention moot. In Woolin, a man killed his baby son while angry, throwing him onto a hard surface. The trial judge instructed the jury through a broad definition of intention, directing them that they could infer that Woolin had intended to kill his son if there was a "substantial risk" of injury. Woolin was convicted,

Development of Insulin using Recombinant DNA Technologies

Development of Insulin using Recombinant DNA Technologies Alistair Jones The use of biotechnology within medicine; diabetes and development of insulin using recombinant DNA technologies Abstract Proteins act as a catalyst for metabolic reactions and responsible for inter and intracellular reactions and signalling events essential for life(Ferrer-Miralles, et al., 2009) Diabetes mellitus is a metabolic disorder with numerous aetiologies; it can be defined by chronic hyperglycaemia which will cause an effect on the metabolism of carbohydrates, fats and proteins. This detrimental effect is from the lack of insulin action, insulin secretion or a combination of them both. Diabetes causes long term damage, dysfunction and failure of a range of major organs. (Consulation, 1999) Through the use of clinical administration missing proteins can be sourced from external sources to reach normal concentrations within the tissular or systemic level. As a number of important studies have all confirmed the importance of the use of strengthened insulin treatment for the reduction and minimisation of long term diabetic complications; it is of great importance and pharmaceutical value that huma n proteins can be sourced (Lindholm, 2002) Through the use of biochemical and genetic knowledge the production of insulin has become available and this industrial scale of therapeutic protein production is the first true application of recombinant DNA technology. (Swartz, 2001, Walsh, 2003) E.coli can be considered as the first microorganism for the production of proteins and is primarily used for genetic modification, cloning and small-scale production for research purposes. Many historical developments within molecular genetics and microbial physiology have been based within this species which has results in a collection of both information and molecular tools. (Ferrer-Miralles, et al., 2009) Discussion Proteins act as a catalyst for metabolic reactions and responsible for inter and intracellular reactions and signalling events essential for life; consequently , a deficiency in the production of polypeptides or production of non-functional of relevant proteins will derive in pathologies which can range from mild to severe (Ferrer-Miralles, et al., 2009). Diabetes mellitus is a metabolic disorder with numerous aetiologies; it can be defined by chronic hyperglycaemia which will cause an effect on the metabolism of carbohydrates, fats and proteins. This detrimental effect is from the lack of insulin action, insulin secretion or a combination of them both. Diabetes causes long term damage, dysfunction and failure of a range of major organs. The characteristics presented with diabetes are weight loss, polyuria, blurring of vision and thirst; the more severe cases will cause ketoacidosis or a non-ketotic hypersmolar state which will lead onto comas, stupor and left untreated death. As the symptoms are often not severe and go undetected for long periods of time, hyperglycaemia can cause pathological and functional changes before a diagnosis can be made. Diabetes causes a multitude of long term affects which include, but not limited to; the failure of the renal system, a two to four times increased risk of cardiovascular disease and potentia l blindness. There are a number of pathogenetic processes which can be involved in the development of diabetes; these will include the processes which destroy the insulin creating beta cells within the pancreas and the creation of a resistance to insulin action ( Alberti, et al., 2006, Consulation, 1999) A combination of metabolic disorders known as metabolic syndrome (MetS) is the combination of hyperglycaemia, hypertension and gout and other cardiovascular risk factors which predict a high risk of developing diabetes. People who have MetS are of the highest risk of the development of type 2 diabetes as it is present up to five times higher within people with this syndrome; this is due to the fact that glucose dysregulation is already present (Alberti, et al., 2006). Type 2 diabetes and atherosclerotic cardiovascular disease can be seen to be of similar ascendants. Inflammation markers have been associated with the development of type 2 diabetes in adults; although this may be part of the autoimmune response they will also reflect the pathogenesis (Schmidt, et al., 1999) Abnormal metabolism of proteins, fats and carbohydrates is caused by the deficient insulin action on target tissues due to the insensitivity or lack of insulin. (Consulation, 1999) Through the use of clinical administration missing proteins can be sourced from external sources to reach normal concentrations within the tissular or systemic level. As a number of important studies have all confirmed the importance of the use of strengthened insulin treatment for the reduction and minimisation of long term diabetic complications; with human insulin being the first line of treatment; it is of great importance and pharmaceutical value that human proteins can be sourced, as this is difficult to do from natural sources (Lindholm, 2002) . We are far past the times of animal sourced insulin’s and we are reaching the turning point in the use of recombinant DNA technologies; which were developed during the late 70’s and uses E.coli as a biological framework for the production of pr oteins of interest through relatively inexpensive procedures. Recombinant DNA technology not only offers the ability to create straightforward proteins but also provides the tools to produce protein molecules with alternative and modified features. (Mariusz, 2011) There are several obstacles in the production of proteins through the use of E.coli however, as it lacks the ability to make post-translational modifications (PTMs) present within the majority of eukaryotic proteins (Ferrer-Miralles, et al., 2009). Recombinant DNA insulin’s are, therefore, gradually being replaced by the more highly efficient insulin analogues (Bell, 2007, Ferrer-Miralles, et al., 2009). Clinically, insulin analogues have been used since the late 1990s, the reason behind insulin modification for subcutaneous injection is to produce absorption properties that better suit the rate of supply from the injection to the physiological need. (Jonassen, et al., 2012) Insulin analogues have the properties of being able to be either rapid acting such as glusine, aspart or lispro or be a long lasting molecule such as glargine and detemir, these can also be used in combination with protamine, these premixed insulin’s provide a more sustained action (Bell, 2007). The combination of biotechnology and the pharmaceutical industry is a product of an evolution within technology and product innovation; which has become a result in advances within science and business practices. The biotechnology based products are thought of as intelligent pharmaceuticals as they often provide new modes and mechanisms in the action and approach to disease control with improved success rate and better patient care. (Evens Kaitin, 2014) Through the use of biochemical and genetic knowledge the production of insulin has become available and this industrial scale of therapeutic protein production is the first true application of recombinant DNA technology. (Swartz, 2001, Walsh, 2003) Although, as insulin is required in such high volumes the product yields of the vast amount of the currently available secretory systems are not currently sufficient enough to make it fully competitive. The current ideas and strategies being used to help improve the efficiency and producti vity of secretion are numerous. (Schmidt, 2004) Cultivation of insulin can be done conveniently within microbial cells such as bacteria and yeast. During the 80’s the FDA approved the use of human insulin produced from recombinant E.coli for the treatment of diabetes, this was the first recombinant protein pharmaceutical to enter the market. Thanks to the versatility and possibilities created through the use of recombinant protein production a large sector of opportunities for pharmaceutical companies opened up. (Ferrer-Miralles, et al., 2009) Since the approval of insulin in 1982 there are now currently more than 200 biotech products available commercially and research has expanded this to over 900 products being tested within clinical trials. Pharmaceuticals are engaged within the development of these products substantially as well as their commercialisation (Evens Kaitin, 2014). This acknowledges the fact that although the microbial systems lack the post translational modifications they are able to efficiently and conve niently produce functional mammalian recombinant proteins. Specific strains of many microbial species have now been created and adapted towards protein production; and the incorporation of yeasts and eukaryotic systems is now in place for protein production. (Ferrer-Miralles, et al., 2009). The use of E.coli expression system is the preferable choice for production of therapeutic proteins, amongst the 151 pharmaceuticals licensed in January 2009 30% where obtained in E.coli, this is due its ability to allow for efficient and economical production of proteins on both a lab scale and within industry (Mariusz, 2011, Swartz, 2001). During insulin production within E.coli the gene is fused with a synthetic fragment encoding for two IgG binding domains which have been derived from staphylococcal protein A. This product is then secreted into the growth medium of E.coli and purified using the IgG affinity. (Moks, et al., 1987) E.coli can be considered as the first microorganism for the production of proteins and is primarily used for genetic modification, cloning and small-scale production for research purposes. Many historical developments within molecular genetics and microbial physiology have been based within this species which has results in a collection of both information and molecular tools. (Ferrer-Miralles, et al., 2009) E.coli flourishes at a temperature of 37Â °C but the proteins are in insoluble form. Fusion protein technology has been able to increase the solubility of over expressed proteins, through the modification of selected amino acid residues allowing for the collection of soluble proteins (Zhang, et al., 1998). Due to the lack of the mechanisms to enable PTMs in bacterial cells protein maturation and disulfide bridges can be, to an extent overcome through the use of protein engineering (Mariusz, 2011). PTMs are crucial in protein folding, stability, processing and activity; therefore, proteins lacking the PMTs may be unstable, insoluble or inactive. However it is possible to synthetically bind PTMs to products, and through genetic engineering of DNA, the amino acid sequence of the polysaccharide can be changed to alter its properties this has been observed within insulin. (Ferrer-Miralles, et al., 2009) For more sophisticated modifications the genetic fusion of two proteins is required (Mariusz, 2011) An increase number of proteins being produced are engineered and tailored to display altered pharmacokinetic profiles and reduce immunogenicity. (Walsh, 2003) Even with the pharmaceutical market progressively producing more protein drugs from non-microbial systems; cell-free protein synthesis and oxidative cytoplasmic folding offers alternatives to the standard recombinant production techniques, it has not effect or impaired the development and progression of products developed within microbial systems proving the robustness of the microbial systems. (Ferrer-Miralles, et al., 2009, Swartz, 2001) In the future Radio Frequency Identification technology will play an important role; however there are some barriers in place for the pharmaceutical supply chain, as there have been concerns raised concerning the potential detrimental effect on the proteins due to the electromagnetic exposure. Alterations have been detected after the RFID however the effect and damages to the protein remain unknown (Acierno, et al., 2010) Works Cited Acierno, R. et al., 2010. Potential effects of RFID systems on biotechnology insulin preparation: A study using HPLC and NMR spectroscopy. Complex Medical Engineering (CME), pp. 198 203. Alberti, K. G. M. M., Zimmet, P. Shaw, J., 2006. Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabetic Medicine, 23(5), pp. 469-480. Bell, D., 2007. Insulin therapy in diabetes mellitus: how can the currently available injectable insulins be most prudently and efficaciously utilised?. Drugs, 67(13), pp. 1813-1827. Consulation, 1999. Definition, diagnosis and classification of diabetes mellitus and its complications. W. H. O., Volume 1. Evens, R. Kaitin, K., 2014. The Biotechnology Innovation Machine—A Source of Intelligent Biopharmaceuticals for the Pharma Industry: Mapping Biotechnology’s Success. [Pre press] submitted to: Clinical Pharmacology Therapeutics, Volume Last excessed, 27/03/2014, p. Avalible from: http://www.nature.com/clpt/journal/vaop/naam/abs/clpt201414a.html. Ferrer-Miralles, N. et al., 2009. Microbial factories for recombinant pharmaceuticals. Microbial Cell Factories , 8(7). Jonassen, I. et al., 2012. Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin. [Online] Available at: http://link.springer.com/article/10.1007/s11095-012-0739-z/fulltext.html [Accessed 2014 March 27]. Lindholm, A., 2002. New insulins in the treatment of diabetes mellitus.. Best Pract Res Clin Gastroenterol, 16(3), pp. 475-92. Mariusz, K., 2011. Engineering of Therapeutic Proteins Production in Escherichia coli. Current Pharmaceutical Biotechnology, 12(2), pp. 268-274. Moks, T. et al., 1987. Large–Scale Affinity Purification of Human Insulin–Like Growth Factor I from Culture Medium of Escherichia Coli. Nature Biotechnology, Volume 5, pp. 379-382. Schmidt, F., 2004. Recombinant expression systems in the pharmaceutical industry. Applied Microbiology and Biotechnology, 65(4), pp. 363-372. Schmidt, M. et al., 1999. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. The Lancet, 353(9165), p. 1649–1652. Swartz, J., 2001. Advances in Escherichia coli production of therapeutic proteins. Current Opinion in Biotechnology, 12(2), pp. 195-201. Walsh, G., 2003. Pharmaceutical biotechnology products approved within the European Union. European Journal of Pharmaceutics and Biopharmaceutics, 55(1), pp. 3-10. Zhang, Y. et al., 1998. Expression of Eukaryotic Proteins in Soluble Form in Escherichia coli. Protein Expression and Purification, 12(2), pp. 159-165.

Original Writing :: Plagiarism Influence Authors Argumentative Essays

Original Writing My writing as a poet has been heavily influenced by writers like Langston Hughes, Nikki Giovanni, Alice Walker and Slam poets such as Black Thought and the Last Poets. These writers write and speak about the struggles and uniqueness of Black culture. Their individual experiences and political stances as well as the influences of other artist are evident in their work. For example in Giovanni’s poem â€Å"Revolutionary Music† she quotes some of the lyrics from Sam Cooke and James Brown to illustrate her personal views on racism and the equal rights movements. Hughes in his piece titled â€Å"Message to the President† skillfully incorporates the political events of his time into his poem using it to sardonically articulate his view on racial inequalities that were occurring in his time. Black Thought and the Last Poets utilize jazz and urban hip hop along with their idea of Black to relay their message. In writing my individual poems, I find it difficult not to incorporate the style of the writers mentioned. I gained my consciousness of Black culture and struggle through the words of these writers their ideas have no choice but to be reflected in my own writing. I wrote a piece titled â€Å"Books not Bombs† which originated during the time the troops were being sent to Iraq to fight a war that was unnecessary in my opinion. The students at my high school and schools around the city were walking out of class to protest in city hall; however, we were told that we would be suspended by the principal if we left. I felt that the administration was silencing our voices by holding us with the threat of suspension. In this poem I used a line from a local pop song from the group OutKast, â€Å"They’re throwing bombs over Baghdad, but what about the bombs that are exploding right here, right now†¦Ã¢â‚¬  Using this mimics Giovanni and Hughes’ incorporation of musica l lyrics of the time to make the piece relatable to the intended audience. I was also influenced by the social political climate that was being hotly debated at the time (war). My particular social influence is reflective of Robert P. Yagelski’s essay â€Å"Who’s Afraid of Subjectivity†. In his essay he used Donald Murray’s experience of writing and rewriting his piece which was reflective of his war years and the political controversy of his time. â€Å"†¦which provided impetus to write the poem and helped and helped shape the very content of the poem.

Humans Adapted

What are some specific ways that we humans have adapted to the physical environment in which we live in? Such as plate tectonics, weathering and erosion, and the form of precipitation. How do/can we adapt to nature and its disaster? Plate tectonics causes earthquakes, which are one of the things that we have to adapt to. Earthquakes are powerful and each time it strikes it separated the land. So over time we as humans have created strategies. To keep us safe and how to remain calm as the earthquakes are coming our way. One thing we do is that we now have a machine called the seismography, that lets us know how strong the earthquake is, when it’s coming and where it’s going to hit. We have also learned how to make our homes stronger and durable, so that it will not be easy for the earthquake to take it down; California is one of those examples. Rain, sleet, hail, and snow are all examples of precipitation. Rain creates floods, it can be very dangerous depending on how much rain we falls down. We have learned how to adapt to the floods. Such as creating drain pipes so the water can go in the sewer so that the flood want create big damages but the drain pipes don’t always work. Sleet is like watery snow and if enough hit the ground and its cold outside then it can turn hard and make the grounds slippery. So we have learned that salt can unfreeze the roads and make it safe to drive on. Hail is small, sometimes big, balls of hard ice falling out of the sky. It can be dangerous and maybe even deadly if the hail is big and it hits you in the right place. We have learn just to not go out when the hail is hard, and to make sure that you are in a builder or house that can protect you if you are out and not protected. As life goes on we will always find more ways to keep our family and ourselves safe from nature’s disasters. Creating more machines and even more knowledge for years to come.

Child Welfare Essay

Children are considered the future of the world. In their hands lie the progress of a nation. They may seem vulnerable but behind those little bodies, there exist a multitude of hidden potential, waiting to be discovered and enhanced. Their competencies becomes apparent once they undergo the development stages of their lives. With the assurance of their family and the society that they will be provided with their needs, children will inevitably become productive members of the society.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   More so, in a study conducted by the Economic and Social Research Council (ESRC), they discovered that children play a key role in strengthening local communities and making people feel safe in their neighborhoods. According to the evidence they found, children are active – both indirectly and directly – in forging neighborly relationships and connections for their parents. They found that the more parents were involved in the lives of their neighbors, the more freedom they gave their children. At the same time, the more social networks children have in a neighborhood, the greater parents’ confidence in the safety of that area (Weller â€Å"Children Play a Key Role in Forging Close Communities†). This study emphasizes children’s role in the community amid portrayal that they are feeble and incompetent.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   It is because of children’s contribution society that various organizations and government agencies introduced child welfare services in order to ensure that the needs of children are met. The term child welfare means a child’s sound well-being. Child welfare covers an array of social services provided to children to guarantee their safety, security and development (Bezeu â€Å"Educational Administration for Canadian Teachers†). Furthermore, it is  Ã‚   connected to ensuring that a child is safe from child abuse or neglect. This requires that a child’s basic needs are met and the child has the opportunity to grow and develop in an environment that provides consistent nurture, support and stimulation. An outcome of this is the development of   children’s sense of identity, an understanding of their ethnic heritage and skills for coping with racism, sexism and other forms of discrimination that remain prevalent in the society (Pecora 12).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Presently, millions of children and young people lack the prerequisites for success, like adequate housing, health care, and nutrition. Thousands are exiled to the outskirts of opportunity. In 2002, reports of abuse and neglect involved more than 2.8 million children, and three children died every day from maltreatment (â€Å"Child Welfare League of America: Fact Sheet†). It is because of these averting data that pushed me to pursue a career in the field of child welfare. I concur with the idea   that the children are our future and with that they must not be deprive of their needs and a healthy environment. They need guidance, compassion and understanding from the people that surround them in order for these children to grow. I also believe that the children’s innocence and weakness should not be exploited by others particularly by adults since they are mostly the ones who possess the capability to this. Instances of neglect and violence are prevalent in a society and as a result, children frequently become victims or become primary targets of these crimes. Many people think that they can   do anything on children since they are perceived to be defenseless and indispensable. It is sad to think that even children’s own mothers abandon them in order to chase after their own dreams or even the notion that a father can inflict harm to his own children.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Because of these frustrating circumstances, I decided to take on the responsibility of protecting children. I want to make a difference in the world and by helping children is a step closer in achieving this goal.   I am driven in instilling to children’s mind that they are entitled to the many good things in life such as having an education, being able to play in the park or having wonderful dinners with their family . Also, I want to emphasize to children that they can become whomever they want to be as long as they put their hearts and minds to it. Through these means, children will feel a sense of significance and belongingness. More so, I can be able to empower the children’s concept on their role in the society which is all-important for the whole of   mankind.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   In achieving these objectives, I believe that I have the necessary qualities needed to become a great child welfare worker. I am very much determined in protecting children, preserving existing familial units, and the promoting children’s development into adults who can live independently and contribute to their community (Pecora 9). My advocacy and my interpersonal and intrapersonal skills is my   powerful combination to be able to function well as a child welfare worker. More so, I am an open-minded and a compassionate person which I believe is important in dealing with children – in understanding their plight and most especially earning their trust which is the first step in helping them.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   If I will be given the chance to work as a child welfare worker, I would like to be more exposed on the global situation on programs and policy for children welfare services so that I can be able to have an overview of the status of children all over the world and have an information on what organizations and the government is doing in ensuring that their basic needs are met and their rights   protected. The information that will be derive from this can help me determine the factors affecting children’s well being in a particular social setting. With this at hand, I can be able to learn of ways on how to combat the problems facing children today. Also, exposure to various scenarios can help me see the problems and effectiveness of other social service programs in which can help me determine what can be applied and disregarded in terms of the current social services offered and utilized by my country.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   In addition, I want to know more about the various agencies and organizations that deal with children’s welfare. Learning about their programs can lead to a realization of a corroborative effort and a coordinated response that will effectively address the children’s needs.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Five years from now, I see myself having a stable career in a field that I am truly passionate about. I can also see myself being financially stable so that I can sufficiently support myself and my family. I would also like to pursue a masters degree that is related to children’s welfare so that I can be able to know more on how to understand children and help solve the problems affecting them. These are my short-term goals.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   For my long-term goals, I want to see myself climb up the ladder in terms of my professional career. Perhaps, envision myself as the head of my local government child welfare service agency or even the State department where I see myself as a responsible and effective leader. Works Cited Bezeau, Lawrence M. Educational Administration for Canadian Teachers. Canada: Copp   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Clark, 2007. â€Å"Child Welfare League of America: Fact Sheet.† Child Welfare League of America. 22    February 2008 . Pecora, Peter J. The Child Welfare Challenge: Policy, Practice, and Research. Aldine   Ã‚  Ã‚   Transaction. 2000. Weller, Susie. â€Å"Children Play a Key Role in Forging Close Communities.† 23 August 2007.   Ã‚  Ã‚  Ã‚  Ã‚   ESRC Society Today. 22 February 2008   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   http://www.esrcsocietytoday.ac.uk/ESRCInfoCentre/PO/releases/2007/april/children.  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   aspx?ComponentId=19628&SourcePageId=19714>.

Tg-BRAF transgenic mice Essays

Tg-BRAF transgenic mice Essays Tg-BRAF transgenic mice Essay Tg-BRAF transgenic mice Essay Molecular dissection of papillose thyroid malignant neoplastic disease patterned advance to ill differentiated carcinoma in Tg-BRAF transgenic mice: Evidence for epithelial-mesenchymal passage and designation of campaigner tracts. Abstraction Mice ( Tg-BRAF ) with thyroid-specific look of oncogenic BRAF ( BRAFV600E ) develop papillose thyroid malignant neoplastic diseases ( PTC ) by 3 hebdomads of age. At 5 months gt ; 90 % of PTCs are locally invasive, and ~50 % have well-defined focal point of ill differentiated carcinoma ( PDTC ) . To look into the PTC-PDTC patterned advance in Tg-BRAF mice, we performed a microarray analysis utilizing RNA prepared from cells collected by optical maser gaining control microdissection from mated samples of PDTC and well-differentiated PTC from the same animate being. Analysis of 8 mated samples hybridized to a Operon microarray with a 35473 oligo denseness found 98 cistrons with consistent look alterations between PTC and PDTC in at least 7 of the 8 paired samples. EASE analysis indicated that cistrons involved in cell adhesion and intracellular junctions were significantly represented, with alterations consistent with an epithelial-mesenchymal passage ( EMT ) . Decreased look of E-cad herin and desmocollin 2 and increased look of procollagen and vimentin, all of which are trademarks of EMT, were observed in at least 7 of 8 PDTC focal point. The upregulation of vimentin in PDTC focal point was confirmed by IHC. There were no consistent look alterations in LEF/TCF or in the snail household, proposing that the Wnt and sonic porcupine tracts are non involved in the initiation of EMT, or in patterned advance to PDTC. By contrast, increased look of PDGF-B and/or D was found in all 8 PDTC focal point. As TGF?I look is increased in the thyroids of the Tg-BRAF mice, these informations are consistent with a function for a TGF?-activated autocrine cringle affecting PDGF in EMT. Decreased E-cadherin has besides been observed in human BRAFV600E positive anaplastic carcinomas, proposing that thyroid malignant neoplastic disease patterned advance in worlds may besides affect EMT. Pathways modulating this passage may be of biological and curative involvement. Introduction The BRAFT1799A mutant is the most common familial alteration in PTC. It is non found in any other signifier of well-differentiated follicular tumor ( 1 ) . BRAF mutants can happen early in development of PTC, as they are present in microscopic PTCs ( 2 ) . Most ( 2,3 ) , but non all ( 4 ) , surveies show that PTCs with BRAF mutants present more frequently with extrathyroidal invasion and at a more advanced phase. Tall cell discrepancy PTCs, regarded as more aggressive, have a really high prevalence of BRAF mutant ( 2 ) . Undifferentiated or anaplastic carcinomas originating from preexisting PTCs have a important prevalence of BRAF mutants, whereas those originating from preexisting follicular carcinoma do non ( 2,5 ) . These informations show that BRAF mutants may be an alternate tumor-initiating event in PTC, and that PTCs with this genotype probably carry a worse forecast. The function of oncogenic BRAF as a tumor-initiating event has been confirmed in mice with overexpression of B -RafV600E targeted to thyroid cells by agencies of the thyroglobulin ( Tg ) cistron booster ( 6 ) . Tg-BRAFV600E mice develop PTCs with high penetrance early in life, and advancement to dedifferentiation, capsular and microvascular invasion, corroborating many of the characteristics found in the human tumours. MATERIALS AND METHODS Experimental animate beings: Creation and initial word picture of the Tg-BRAF2 ( mice with thyroid-specific look of BRAFV600E ) have been described ( 6 ) . Mice were house in. All described processs were approved by the institutional carnal commission. Thyroid aggregation and optical maser gaining control. Animals were euthanized with CO2 and thyroids collected and instantly frozen in OTC. Frozen subdivisions were stained with H A ; E and examined by diagnostician ( YN ) for WD and PD malignant neoplastic disease. Twelve consecutive subdivisions ( 7.5 millimeter ) were taken from parts found to hold a PD focal point. The consecutive subdivisions were stained with HistoGeneTM LCM Frozen Section Staining Kit ( Arcturus Bioscience, Inc. , Mountain View, CA ) and cells from PD focal point and a representative part of WD malignant neoplastic disease were isolated utilizing the artsus Arcturus PixCell II optical maser gaining control microscope System. RNA was isolated from the optical maser captured cells utilizing PicoPureTM RNA Isolation Kit Kit ( Arcturus Bioscience, Inc. , Mountain View, CA ) and so subjected to 2 unit of ammunition messenger RNA elaboration utilizing the messageAMP RNA elaboration kit ( Ambion, Austin, TX ) . Microarray analysis. The mouse 70-mer oligonucleotide library version? ? ? consists of? ? ? optimized oligos ( Qiagen ) and was arrayed and printed as antecedently outlined. The complete cistron lists can be viewed at? ? ? . Fluorescence-labeled complementary DNA were synthesized from amplied RNA utilizing an indirect amino allyl labeling method via an oligo ( dT ) -primed, change by reversal RNA polymerase reaction. The complementary DNA were labeledAmplified RNA was with monofunctional reactive cyanine-3 and cyanine-5 dyes ( Cy3 and Cy5 ; Amersham, Piscataway, NJ ) . Pairwise hybridisations were done between labeled complementary DNA matching to unstimulated versus doxycycline-treated cells for each of the cell lines and clip points. In add-on, to increase the statistical power of the experiment, paired hybridisations were done to compare look between cell lines at the same clip points before or after oncoprotein activation. Detailss of hybridisation and rinsing conditions can be found at? ? ? . Imagin g and informations coevals were carried out utilizing a GenePix 4000A and GenePix 4000B ( Axon Instruments, Union City, CA ) and associated package from Axon Instruments, Inc. ( Foster City, CA ) . The microarray slides were scanned with double optical masers with wavelength frequences to excite Cy3 and Cy5 fluorescence emittance. Images were captured in JPEG and TIFF files, and DNA musca volitanss were captured by the adaptative circle cleavage method. Information extraction for a given topographic point is based on the average value for the signal pels minus the average value for the background pels to bring forth a cistron set informations file for all the DNA musca volitanss. The Cy3 and Cy5 fluorescence signal strengths were normalized. Data standardization was done in two stairss for each microarray individually ( 19-21 ) . First, background-adjusted strengths were log transformed, and the differences ( R ) and norms ( A ) of logtransformed values were calculated as R = log2 ( X1 ) log2 ( X2 ) and A = [ log2 ( X1 ) + log2 ( X2 ) ] / 2, where X1 and X2 denote the Cy5 and Cy3 strengths after deducting local backgrounds, severally. Second, informations focus was done by suiting the array-specific local arrested development theoretical account of R as a map of A. The difference between the ascertained log-ratio and the corresponding fitted value represented the normalized log-transformed cistron look ratio. The statistical analysis was done for each cistron individually by suiting a mixed-effects additive theoretical account. Premises about theoretical account variables are the same as described in mention ( 7 ) , with array effects assumed to be random and intervention and dye effects assumed to be fixed. Statistical significance of differential look was assessed by ciphering Ps and seting for multiple hypotheses proving by ciphering false find rates ( 8 ) . Estimates of fold alteration were besides calculated. Data standardization and statistical analyses were done utilizing SAS statistical package bundle ( SAS Institute, Inc. , Cary, NC ) . Gene note was supplemented with human and mouse homologues for unknown oligos. Immunohistochemistry: Animals were euthanized with CO2 and thyroids collected and instantly placed in 4 % PFA. After 24 hours they thyroids were placed in 70 % ethyl alcohol and embedded in. ? ? ? was? . Consecutive subdivisions from part found to incorporate a PD focal point were? ? ? and incubated with indicated antidbodies. Immunoreactive was detected by incubating with and? Consequence Gene look profile of WD and PD thyroid malignant neoplastic diseases from Tg-BRAF mice: Tg-BRAF2 mice develop PTC by 3 hebdomads of age and by 12 hebdomads of the animate beings had locally invasive PTC and about 50 % had focal countries of PDTC ( 6 ) . The PDTC were identified by a solid growing pattern incorporating fusiform cells ( Fig 1A ) . Extra verification that the focal point were PDTC was provided by an increased figure of mitotic ( Fig 1B ) and Ki67 positive cells ( Fig 1C ) every bit good as the presence of necrotic/apoptosis cells ( Fig 1C ) . To place cistron look alterations involved in the passage from the WD PTC to the PDTC we used LCM to insulate cells from from 8 alone ill differentiated focal point and a representative country of WD PTC from the same Tg-BRAF2 mice. RNA was isolated from the optical maser captured cells, amplified, labeled with Cy5 or Cy3 and hybridized to operon? ? ? bit. This identified? ? ? cistrons with important look alterations ( P lt ; 0.05 , FDR lt ; 0.1 ) and of these? ? ? had an look alterations that was greater 1.5 crease. There were? ? ? cistrons merchandises that decreased and? ? ? that increased. To place signaling tracts that may intercede or lend to these look changes we used EASE analysis to compare our informations set to the Gene Ontology and KEGG databases. This found that cistrons involved in tight junction, ? ? and where significantly represented in the PDTC information set. Closer scrutiny indicated that that cistrons involved in tight juntction and cell contact were decreased, while the intermediate filament cistron increased in look ( Table 2 ) . These alterations are consistent with an EMT. To corroborate cells in the PDTC had undergone EMT a 2nd set of thyroids from Tg-BRAF2 animate being were IHC stained for E-cadherin and vimentin, hall Markss of EMT. tracts Mentions 1. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High Prevalence of BRAF Mutations in Thyroid Cancer: Familial Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma. Cancer Res 2003 ; 63:1454-7. 2. Nikiforova MN, Kimura ET, Gandhi M, et Al. BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Ill Differentiated Carcinomas Arising from Papillary Carcinomas. J Clin Endocrinol Metab 2003 ; 88:5399-404. 3. Xing M, Westra WH, Tufano RP, et Al. BRAF Mutation Predicts a Poorer Clinical Prognosis for Papillary Thyroid Cancer. J Clin Endocrinol Metab 2005 ; . 4. Puxeddu E, Moretti S, Elisei R, et Al. BRAF ( V599E ) mutant is the taking familial event in grownup sporadic papillose thyroid carcinomas. J Clin Endocrinol Metab 2004 ; 89:2414-20. 5. Namba H, Nakashima M, Hayashi T, et Al. Clinical deduction of hot topographic point BRAF mutant, V599E, in papillose thyroid malignant neoplastic diseases. J Clin Endocrinol Metab 2003 ; 88:4393-7. 6. Knauf JA, Ma X, Smith EP, et Al. Targeted look of BRAFV600E in thyroid cells of transgenic mice consequences in papillose thyroid malignant neoplastic diseases that undergo dedifferentiation. Cancer Res 2005 ; 65:4238-45. 7. Wolfinger RD, Gibson G, Wolfinger ED, et Al. Measuring cistron significance from complementary DNA microarray look informations via assorted theoretical accounts. J Comput Biol 2001 ; 8:625-37. 8. Reiner A, Yekutieli D, Benjamini Y. Identifying differentially expressed cistrons utilizing false find rate commanding processs. Bioinformatics 2003 ; 19:368-75.

Ethical Relativism Essay Sample

Ethical Relativism Essay Sample Ethical Relativism Essay Relativism acknowledges that different points of view are valid in equal measures as individuals differ in their approach to truth. In ethics, relativism stipulates that moral beliefs tend to be relative. Thus, dependent on the individual or society. This theory indicates that there is no universal right or wrong, therefore, morality is subjective rather than objective as illustrated by the ethical objectivism. In light of this, this essay analyzes the two forms of ethical relativism- personal relativism and cultural relativism. Further, it looks at the arguments for and shortcomings of relativism. Morality is relative as different people uphold diverse beliefs on the same. For instance, eating pork is permissible in some societies while others like Islam detest such an act. In essence, morals change with time as per the evolving social norms of particular communities. The subjective relativism or personal ethical relativism attribute morality to individuals’ perception. In this case, a person has sovereignty over own thoughts, actions, and behavior. He/she dictates what is right or wrong. Cultural or conventional ethical relativism is another form of relativism that view morality being dependent on what society dictates to be wrong or right. According to this version, a person acts based on the values and norms of his community. In cultural relativism, a person’s will is subordinate the cultural majority‘s will. Nonetheless, a society’s definition of morality may still differ from another. In both subjective and conventional view, there is no standar d and objective form of morality. Arguments for ethical relativism Tolerance of differences: this is a pluralist position to morality which promotes diversity of opinions. Different cultures or people exhibit diverse moral beliefs that require tolerance as we might not subscribe to them. One’s view should not be superior to another’s point. Relativism bears a diversity of moral views. The differences in views create a complex and unique world with constant change and borrowing of ideas. The commonality in opinions would generate redundant societies. From diversity, innovation and creativity exist. Therefore, subjective moral beliefs occur and not objective moral truths. David Hume (1711-76) postulates that moral beliefs arise from emotions or sentiments and not reason. Situational differences also place different people and communities at divergent levels. Hence, implausible to have common moral principles for all persons. Moreover, ethical values arise from real-life interactions as per the circumstances. Shortcomings Critics of ethical relativism state that moral practices across societies may differ but the fundamental moral principles that underlie such practices should not. For instance, dress codes and local customs differ but aspects such as killing, political repression or torture remain governed by the universal moral standards thus wrong. To some extent, ethical relativism promotes social conformity. For instance, if a society believes that child marriage is morally permissible, a member of such a group must accept such practices as right. It hinders social change and improvement within a society. Diverting from such acts would be termed immoral. Disagreements may constitute objectivity on a view thus not merely the presence of subjectivity. Ethical relativism poses a self-contradictory approach as two mutually exclusive opinions would be both right. In addition, ethical relativism tends to promote outrageous practices like killings, rape or child abuse if they are perceived ‘right’ by standards of the concerned society. Hence, depriving the society the ability to initiate moral objections to counter such social vices. In conclusion, ethical relativism is promoting diversity of moral concepts. However, its relative approach poses several disadvantages calling for the need to uphold objectivity to some moral principles.

The best night jobs you can work during the graveyard shift

The best night jobs you can work during the graveyard shift Not everyone is meant for a 9-to-5 life. Or maybe you’re looking for a side hustle to supplement your 9-to-5 life. Or†¦maybe you’re a vampire. Whatever the case may be, we don’t judge- and we have some of the best jobs out there for night owls. 1. Air Traffic ControllerThis is not your quiet, sit-back-and-read kind of night job. It’s a â€Å"pound that espresso, because you need to be on it† night job, one for people who can be organized and diligent at any hour of the day or night. Air traffic controllers are responsible for coordinating aircraft takeoffs and landings at airports and communicate directly with pilots about runway conditions, weather, and other issues that can impact a safe takeoff or landing.To score this job, you’ll need a bachelor’s degree, and to complete a Federal Aviation Administration training program. Because this is a highly specialized job that requires amazing attention to detail and the ability to stay calm under any conditions, it’s a lucrative one as well: the median salary is $122,950 per the U.S. Bureau of Labor Statistics.2. Paramedic/EMTSpeaking of jobs that require calm under pressure, paramedics and EMTs are high on that list as well. This is a job that can have you on call during any shift of the day, responding to emergency calls and helping people in a variety of medical or emergency situations.To become a paramedic/EMT, you’ll need an associate’s degree and/or a certificate from a paramedic-specific allied health programs (some require up to 1,200 hours for certification). All states require candidates to pass a national exam before they can be certified and ready to hit the streets. The median salary is $32,670 per the U.S. Bureau of Labor Statistics.3. Rideshare Service DriverWhile there aren’t quite as many people out and about at midnight as, say, 6 p.m., plenty of people still need to get around at all hours of the night- coming home f rom bars, clubs, working late, etc. That’s often where rideshare drivers for companies like Uber and Lyft come in.To become a rideshare driver, you’ll need a valid driver’s license and a decent vehicle, plus you’ll need to pass a background check. Rideshare drivers can make up to $30 an hour, depending on location and tips.4. Casino DealerIf you’ve ever been in a casino, you might have noticed they’re not big on clocks- all the better to keep people gambling all night without realizing how late it is. That means casinos have staff on hand at all times of day or night, including the graveyard shifts. Dealers lead casino games (craps, blackjack, poker, and more) and handle money transactions on behalf of the casino. Not everyone lives near a casino, but if you do, it can be a good option for your night job.To become a casino dealer, you will need a high school diploma or equivalent, and may need to pass a background check (given that youâ€⠄¢ll be dealing with significant amounts of money). You should also have good math skills and attention to detail.5. Security GuardWhen you think of a night job, this might be the one that comes to mind. Security guards are responsible for making sure that premises are secure all night long, even if no one else is there. Depending on the company, it can be a very low-stress night job, letting you multitask with schoolwork, reading, or other activities that let you keep an eye on what’s going on.To become a security guard, you’ll need to have a high school diploma or equivalent, plus receive on-the-job training. You may also need to be trained in handling weapons, depending on the job.

In relation to the standard of care in Negligence actions, the Essay

In relation to the standard of care in Negligence actions, the characteristics of the defendant are never taken into account. Examine this statement, supporting your answer with authorities - Essay Example Tort is pertaining to the act of breaching a non-contractual civil duty that is commonly owed to the public2. In general, the nature of torts can either be intentional or unintentional. Under intentional torts, defendants are being accused of purposely hurting another person (i.e. slander, libel, assault cases, etc.). On the other hand, unintentional torts include negligence which For example, healthcare ethics and law is an essential part of the daily medical practices of health care professionals. Specifically the study of healthcare ethics focuses on the evaluation of merits, risks, and other social concerns with regards to the activities provided by the healthcare professionals to the patients. In relation to medical practices, the code of ethics and the legal implications of healthcare profession must be followed carefully to ensure that the best medical practices will be rendered to the patients4. The study of health ethics and law has laid its foundation on the respect for Human Rights. Under the law of obligation, healthcare professionals are obliged to give respect to the patients’ autonomy particularly when it comes to decision-making for their own treatment as well as being informed with the matters related to the process of their treatment5. Likewise, health care professionals should also observe the practice of non-maleficence, beneficence, and justice6. Aside from doing only good actions that will further improve the welfare of the patients, healthcare professionals are required not to injure the patients in any way. By being fair to all, healthcare professionals can avoid being liable for any future legal claims. For example, in violation to the healthcare ethics, members of the healthcare professionals may end up unconsciously or unintentionally harming the patients. In the process wherein the healthcare professionals are found guilty of harming the patients,

Answer these questions Essay Example | Topics and Well Written Essays - 500 words

Answer these questions - Essay Example Indeed he not only wanted to impose Nazism on Germans, but he wanted to impose on all Europeans and perhaps even on everyone in the world. He believed everything he did was right and everyone should agree with him. 27. Hitler believed that all Jews were different than Germans. He wanted Germans to fit into the Aryan ideal and to be blue-eyed and blonde-haired. He desired a people that did not look at all Semitic. To Hitler, Jews could be detected by their appearance. This was another example of his anti-Semitism which led to the Holocaust. 3. Hitler definitely thought that young people should indoctrinated early on. He wanted all German students to worship him and agree with everything he said. That is why he created the Hitler Youth. Truth was whatever he said it was. 12. Hitler was a war leader because he chose to start wars everywhere in Europe. He was deluded if he thought that other people were starting wars against him. His surprise attack on the Soviet Union is a good example of this. Every time he made an agreement with someone he broke it. He was a war leader by choice. 21. In the warped way that he looked at the world, Hitler probably believed he was humane. He thought it was nice to kill people because he was doing it for a larger reason—the betterment of humankind. He had probably convinced himself that he was humane and good while at the same time committing evil acts. He was certainly

Topics in Cultural Studies Essay Example | Topics and Well Written Essays - 1000 words

Topics in Cultural Studies - Essay Example Globally, cultures have faced colonization, which facilitated the confrontation of the non-western and western cultures (Oberg, 2010). This led to the realization that non-western cultures occurred as outposts in the colonial empires developed by Europeans. This loss of centeredness of the Native American culture led to the weakening of their traditions, political and social systems, as well as practices. This means that the European culture had immense impact on the culture of Native Americans. Native Americans occupied the vast American land before their interaction with Europeans. The natives can be considered as the indigenous or original occupants of North America. They comprised of people from distinct American ethnic and tribal groups. Despite their interactions with the Europeans and the subsequent loss of centeredness, some of the tribes and ethnic groupings survived as intact political communities (Schwab, 2010). The first contact of Europeans with Native Americans came aft er the exploration of Christopher Columbus (Oberg, 2010). Thereafter, the 15th century saw an influx of Europeans into the American continent and they brought Africans as their slaves. This led to widespread confrontations, adjustments and conflicts between the two societies. The lives of Native Americans were uncomplicated because they followed traditional practices in society and political set-ups. For instance, they lived as hunters and gatherers within well-set communities. In addition, the societies told their histories on oral traditions. In most of the groupings, women performed sophisticated cultivation of staple foods such as squash, maize and beans (Schwab, 2010). The cultures of the indigenous people were extremely dissimilar from the cultures of agrarian, proto-industrial and Christian cultures. The native cultures were matrilineal meaning that they occupied land for communal use, which included activities such as agriculture and hunting (Oberg, 2010). This differed from European cultures, which followed patriarchal trends. The European society had concepts for developing individual property rights on land. This differed from the rights and approaches of Native Americans on land. These cultural differences between the immigrant Europeans and Native Americans, and the shifting alliances between the nations led to extreme political tensions, social disruption and ethnic violence (Schwab, 2010). The natives did not only suffer a loss of centeredness in social and political activities, but they also contacted the infectious Eurasian disease, which they had not developed or acquired immunity. This epidemic led to immense loss of life for the indigenous population (Oberg, 2010). The cultural conflicts between the Europeans and the natives resulted from their differences in approaches such as religion, social practices, land and political rule. The Europeans wanted to impose a religious system on the natives. This was met with resistance from the natives because they only wanted to commit to their religious system. However, the Europeans relentlessly forced Christianity on the natives. The first European missions to encounter the natives were trappers and fur traders. The missionaries and colonists then followed them. Miner migrants and settlers began arriving later, and they heightened the

River Woods TEAM Assignment Essay Example | Topics and Well Written Essays - 250 words

River Woods TEAM Assignment - Essay Example First and foremost, the plant manager should possess competent knowledge, skills and expertise in the various domains he/she is expected to oversee. Knowledge is power, goes the saying. Thus, if the manager possesses the knowledge and expertise required, people will seek out his opinion, they will listen to him/her and will always perceive him/her as an expert. This way, he/she will be able to gain authority. Secondly, the plant manager should have authority. He/she should be responsible and accountable for all the responsibilities under him/her. Thirdly, the plant manager must have courage and confidence. In simpler terms, the plant manager needs confidence so as to know that he/she has power, and needs courage to use the power. For personal power to exist, it has to be acknowledged and used. The plant manger should be in position to always do and say what is needed. He/she should have the confidence to ask anything he/she is in need of. Finally, the plant manager has to possess good interpersonal relationship skills. Thus, in order to prevent the looming unionization of the firm as a result of inevitable complains from the employees, the plant manager should be in a position to gain power through his/her relationship with them. He/she should be able to build trust and closer relationships with them, so as to make it easy to influence them. The fact that the plant is decentralizing its management structure, call for a plant manager who will be in direct touch with the employees.teh manager will be in regular contact with them, thus, he/she to develop a good rapport with them. This can only be done through ensuring the new plant manager is endorsed with the necessary power and resources required to command authority from the employees. Thus, In order to ensure that the new plant general manager is in a position to accomplish the assigned duties, the following actions have to be taken. First, legitimate/position power has to be

Explain what the digital divide is; in your answer discuss the Research Paper

Explain what the digital divide is; in your answer discuss the advantages and disadvantages of improving the digital divide - Research Paper Example What does it mean? How did it happen? Does it have any positive or negative effect on our society? What benefits can be had from promoting a digital divide? Should the digital divide be promoted within our society as something that should be supported or not supported? These are but a few of the questions that I am looking forward to answering within the next few pages. I would like to start off this paper by presenting the readers with a basic discussion of the digital divide and its meaning. While the economic divide pertains the method by which the people of the world are separated by the amount of money that they have, the digital divide separates people in terms of their existing or non-existing access to the internet and other forms of communication technology. According to experts, the digital divide exists as a barrier between the urban and rural areas (Rouse, 2005). Upon closer inspection, one will come to the realization that the digital divide, also known as the digital split, refers not only to the people who have easy access to the internet and those who dont, but also among those who have or dont have access to information and communications technology. The term digital divide was then coined, in the 1990s in order to help explain the complex scenario. Due to the globalized market that exists between countries, the presence of the internet and other forms of telecommunication that can help ease the transfer of business information has become one of the utmost important business tools in our era. However, not all countries have state of the art information and communication technology infrastructures in place so the digital divide has already gone beyond borders, thus creating what is now known as the Global Digital Divide. Therefore, the digital divide is not limited to the social or economic statues of people alone. It also includes the members of society who use almost obsolete computers on infantile internet

Learning Styles and Lifelong Learning Process Research Paper

Learning Styles and Lifelong Learning Process - Research Paper Example Guild and Garger (1998) implied on their studies that by completely understanding an individual’s style of learning would allow educators to construct adequate teaching methods that would promote higher learning. For the last fifty years, many researchers have understood the concepts of learning styles. Sims and Sims (1995) have specified that students will be able to develop higher levels of learning through these concepts of learning styles and how these styles influence educators to construct sufficient teaching methods. Studies of Dunn and Dunn (1992) presented that individuals respond to learning in a more positive manner through the utilization of adequate teaching methods that suit them. With the case study, students have manifested greater learning when they were taught using their preferred teaching methods because they were able to absorb the concepts of the subject matter easily. These students have shown improved scores when it comes to tests and exams. It is said that if an educator makes use of the students preferred teaching methods, the students tend to be more attentive. This just shows that if educators would be able to grasp solely their students’ preferred learning styles, these educators would be able to promote enthusiasm among their students to learn more. Through effective teaching methods, the study stated that the students reflected more aggressive behavior toward learning, which means that these students are more willing to learn if they will be able to understand their educators’ method of teaching. In short, learning styles and teaching methods have a deeper association. As stated earlier, I took some tests that would determine my preferred learning style as a student. Before I present the results that I got, let me first introduce to you what learning styles are all about. Ross, Maureen, and Schultz (2001) stated on their studies that learning is often times a process of remembering concepts and putting these concepts into actions after  further studies. They further added that learning is a two-way process, gathering information and then utilizing the information.  

Explain what the digital divide is; in your answer discuss the Research Paper

Explain what the digital divide is; in your answer discuss the advantages and disadvantages of improving the digital divide - Research Paper Example What does it mean? How did it happen? Does it have any positive or negative effect on our society? What benefits can be had from promoting a digital divide? Should the digital divide be promoted within our society as something that should be supported or not supported? These are but a few of the questions that I am looking forward to answering within the next few pages. I would like to start off this paper by presenting the readers with a basic discussion of the digital divide and its meaning. While the economic divide pertains the method by which the people of the world are separated by the amount of money that they have, the digital divide separates people in terms of their existing or non-existing access to the internet and other forms of communication technology. According to experts, the digital divide exists as a barrier between the urban and rural areas (Rouse, 2005). Upon closer inspection, one will come to the realization that the digital divide, also known as the digital split, refers not only to the people who have easy access to the internet and those who dont, but also among those who have or dont have access to information and communications technology. The term digital divide was then coined, in the 1990s in order to help explain the complex scenario. Due to the globalized market that exists between countries, the presence of the internet and other forms of telecommunication that can help ease the transfer of business information has become one of the utmost important business tools in our era. However, not all countries have state of the art information and communication technology infrastructures in place so the digital divide has already gone beyond borders, thus creating what is now known as the Global Digital Divide. Therefore, the digital divide is not limited to the social or economic statues of people alone. It also includes the members of society who use almost obsolete computers on infantile internet

The Spanish Artist Essay Example for Free

The Spanish Artist Essay Francisco Jose de Goya y Lucientes (1746-1828) was born in Aragonese in a small town of Fuendetodos on March 30, 1746. The first period of Goya’s painting career may have started in1763. He was then an aspiring young painter and most of his paintings depict the everyday life of ordinary people, such as in â€Å"The Parasol† painted in 1777, â€Å"The Junkman† painted in 1779, and The Picnic at the Edge of the Manzanares River painted in 1776. The styles vary depending on his subject. The bright light on the Parasol reveals his happy mood in painting the life of the monarch. The style depicts the life of ordinary people, which to me reflect their struggles and hope. Next period was when he was appointed in the palace under Charles III, in 1786 probably up to 1792 when he contracted a disease that changed his view. The topics of his paintings then were about monarchs and the relative peace the people enjoyed. The painting style depicts happiness and vitality of life as most of his paintings use bright light and lively colors. Perhaps the last period was during 1792 up to the last years of his life. The topics of his paintings were gloom probably because of his disease and his analysis of the development at the time as depicted in his Saturn Devouring his Son painted in 1819 and Old Men Eating Soup painted in 1819. The styles reflect his feelings during the time he contracted a disease that made him deaf and the last years of his life. The nude paintings in 1797, the Snowstorm, and the paintings mentioned earlier reflect pessimism and fear. Work Cited Goya http://www. spanisharts. com/prado/goya. htm Goya: Back to Romanticism http://arthistory. heindorffhus. dk/frame-Goya. htm

British Airways PESTLE Analysis

British Airways PESTLE Analysis The macro environment will be described by the PESTEL analysis, which helps to analyze general, long-term market influences. This is the best tool to analyse the external environment. It serves as a basic analytical tool for knowing market decline or growth. The framework helps to understand the impact of legal, political, economical, social and technological factors for the business environment. It helps to understand how the external environment may create opportunities or threats for an organization. The six different environments are often referred to as PESTAL and allow a PESTAL analysis to be conducted this allows the organisation to review and consider the environment in which it operates. The PEST factor that has contributed to the airlines industry for many years, but has brought a drastic change was from the disaster on September 11th 2001. (P)olitical: Airlines have to work within an operating restrictions. Alliance with other airlines increases the reachability of the airlines on top of it route alliance helps the alliance members to embark on political benefit mutually. Last decade was one of the testing times for the airline industry in terms of security with events like terror attacks across US in 2001 and in UK in 2005 which caused political imbalance and crisis. Customer confidence was all time down due to the terror attacks in the past 10 years and has resulted in strict safety laws in the US and European skies for airlines. Currentlys even the product and price are in the control of the government with the restrictions on flying. Though the open skies policy does exists it is not adopted by majority of the players and is still biased. Although great reforms have taken place, giving BA opportunity to grow and compete with other airlines. BA being a deregulated company needs processes which allow fast decision making. BA must consider the influence of the political factors along with the ecological and environmental issues with more emphasis on legal regulations on employee and customer interest. Political environment concerns the role of the government and its affects in an organisation it also includes the extent to which the government intervenes in the economy. Due to the terrorist attack many airlines such as British Airways stopped flights to certain countries such as the middles east and the main countries involved with the fear of their planes being attacked. This is therefore caused up a political stir with the fact that Britains fear them maybe the next victims of terrorist attacks. This has had a negative effects on the airlines as they have lost out on a lot of money because of the stoppage of flights to certain destinations. The authorities have had to make sure that certain rules have been put into place to make sure that the airlines are safe and that they abide by the rules. British Airways have had to rely on the political and environment effects on the feedback that they get to decide on what course if action to take on the airline. (E)conomical: The amount of economic activity in the economic environment is extremely important. The economic environment for airline industry in Europe can be described as difficult. In particular, challenges arise from the co-occurrence of adverse natural factors (especially for BA the ash storm). The global economy experienced a sharp downturn during the last decade, and this affected the air travel demand. In 2008 the economy of the developed countries as well as from the emerging markets experienced a dramatically decrease in growth. The airline industry lost a huge part of its usual profits. These changes lead to a change in demand; costumers are not ready and not able to pay former prices for the airlines. Some competitors of BA decrease there price level already. The demand for air travel is characterised by a high income elasticity.Therefore, as the world economy grows, the demand for air travel will also improve. The political situation in Iraq has helped to drive oil prices to a record high and for BA, the oil price rise might add  £100 million to their costs. In response, the cost of fuel surcharges is always at risk . BA is in the business of transporting people to and from worldwide destinations for both business and pleasure. If the international economy slows down, business trades less and fewer business people will use planes. Equally, people may choose less exciting holidays. Capacity in Europe outstrips demand, which leads to rate wars, equaling lower yields for companies. Economically, alliances lead to a control on capacity, therefore reducing competition and increasing yields. Alliances also reduce the near term possibilities of airport expansion. By code sharing airlines are able to not only split costs but to offer services and enter markets, they might ill afford to do on their own. This leads to less aircraft at airports, less space being required, and is another way in gaining access to prime airports, which can expand no further. (S)ocio-Cultural (Demographical / Sociological): On an average older fliers in European countries force airlines to develop new strategies in relation to their target groups. This is also required in view of the fact that higher numbers of commuters and the demand of lower cost airlines show an attitude change regarding airlines, potentially causing image problems for companies giving higher-cost air service. Airline customers use brand appeal as the main factor when they come to use airline service. Thus, this changing demand and lifestyle influenced airlines to concentrate on the look of their airlines and build powerful brand to gain small gain rather than loosing market share. The social and cultural influences on business vary from country to country however it is important that such factors are considered and include demographic and cultural aspects. These factors affect customer needs and the size of potential markets. Demographic changes have resulted in the development of the à ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒâ€¹Ã…“greyà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒ ¢Ã¢â‚¬Å¾Ã‚ ¢ market who are spending more on leisure and travelling. Lifestyles, tastes and fashions are all changing; customers require opportunities to visit new and interesting, often long-haul, destinations. (T)echnological: In the airline industry, companies are forced to invest huge sums into RD measures to foster technological development and be cutting-edge. Currently, the focus lies in the fields of security and alternative energies. Advance technology is used by BA to increase engineering and the service quality of the flights which are the route to competitive advantage. In order to profitably satisfy customer needs, an organisation must understand its external and internal situation including the customer, the market and its own capabilities. Furthermore, it needs to understand and adapt to the dynamic and uncontrollable factors of the environment in which it operates. The technological environment is ever changing and therefore it is essential that a structured, detailed and continuous analysis of the principal dimensions of the technical environment is made. Technology in this industry is fast moving and very expensive. Alliances, give the opportunity for joint investment ventures, such as shared check-in systems. (E)cological: In view of high media covering, ecological influences become increasingly important. Especially airline companies have to show that they responsibly use the available resources and care for the environment. Following, BA reduced fuel and energy consumptions, which required improvements in engine technology and aerodynamics. BA is the airline which started reporting their environmental results 2 decades back. They make sure that they have least impact on the environment by more efficient operations, latest technology-engines and alternative fuels. They have goals of having zero waste to landfill in UK-2010, reduce the average noise per flight, cut down the CO2 emissions by half-2050 and improve in carbon efficiency by 25%-2025. For the ecological factors they have developed special programes for controlling climate change by controlling the carbon dioxide emissions. In order to make world a nicer place to live they are concentrating on recycling and reducing their waste material. (L)egal: A significant legal factor affecting BA is the power of trade Unions. BA has suffered many strike actions (August 2004 and August 2005) and is aware of the implications that the trade unions can cause. The walkout that recently happened in March 2010, expected to last three days, had forced the airline to cancel thousands of flights. A total of 1,100 flights out of the 1,950 flights scheduled to operate during the walkout were canceled. The airline had leased planes and crew from rival carriers to take up some of the shortfall. The Unite union of cabin crew had gathered some support from unions in the United States, Germany and Spain for its action taken to protest a pay freeze and changes to working conditions but the other unions had so far stopped short of pledging direct action that would affect BAs ability to refuel and service its planes. Talks broke down over a pay freeze and staffing changes. Analysts estimated that BA had lost more than 25 million pounds because of canceled tickets and the cost of contingency plans, which include leasing fully crewed planes from other airlines. Prime Minister Gordon Brown called for the strike to be called off immediately. Unite had planned a second, four-day walkout to begin March 27 and had said more strikes will be scheduled for after April 14 if the dispute was not resolved. It had pledged not to walk out over the busy Easter period. This is a case of cabin crew crisis but is because of the legal problems that BA faces quite often on regular basis. Firm resolution to this problem should be found to reduce risk and increase the returns. PESTEL analysis is a useful strategic tool for product development, sales planning, executing strategies and operational planning as well. It checks that the firms result are in line with the external impact of changes.

Everything You Need to Know about Vitamins :: Science Biology

Everything You Need to Know about Vitamins Vitamin, any of the organic compounds required by the body in small amounts for metabolism, to protect health, and for proper growth in children. Vitamins also assist in the formation of hormones, blood cells, nervous-system chemicals, and genetic material. The various vitamins are not chemically related, and most differ in their physiological actions. They generally act as catalysts, combining with proteins to create metabolically active enzymes that in turn produce hundreds of important chemical reactions throughout the body. Without vitamins, many of these reactions would slow down or cease. The intricate ways in which vitamins act on the body, however, are still far from clear. The 13 well-identified vitamins are classified according to their ability to be absorbed in fat or water. The fat-soluble vitamins-A, D, E, and K-are generally consumed along with fat-containing foods, and because they can be stored in the body's fat, they do not have to be consumed every day. The water-soluble vitamins-the eight B vitamins and vitamin C-cannot be stored and must be consumed frequently, preferably every day (with the exception of some B vitamins, as noted below). The body can manufacture only vitamin D; all others must be derived from the diet. Lack of them causes a wide range of metabolic and other dysfunctions. In the U.S., since 1940, the Food and Nutrition Board of the National Research Council has published recommended dietary allowances (RDA) for vitamins, minerals, and other nutrients. Expressed in milligrams or international units (IU) for adults and children of normal health, these recommendations are useful guidelines not only for professionals in nutrition but also for the growing number of families and individuals who eat irregular meals and rely on prepared foods, many of which are now required to carry nutritional labeling. A well-balanced diet contains all the necessary vitamins, and most individuals who follow such a diet can correct any previous vitamin deficiencies. However, persons who are on special diets, who are suffering from intestinal disorders that prevent normal absorption of nutrients, or who are pregnant or lactating may need particular vitamin supplements to bolster their metabolism. Beyond such real needs, vitamin supplements are also often popularly believed to offer "cures" for many diseases, from colds to cancer; but in fact the body quickly eliminates most of these preparations without absorbing them. In addition, the fat-soluble vitamins can block the effect of other vitamins and even cause severe poisoning when taken in excess.

The Red Tent by Anita Diamant :: Red Tent Anita Diamant Essays

The Red Tent by Anita Diamant The author and her times   Ã‚  Ã‚  Ã‚  Ã‚  Anita Diamant, author of the historic fiction novel, The Red Tent, is a devout Jewish-American living in Newtonville, Massachusetts with her husband and daughter, Emilia. She has written five books about contemporary Jewish life, The Red Tent being her first novel.   Ã‚  Ã‚  Ã‚  Ã‚  Diamant may have been influenced by the recent resurgence of creating Midrashim, or stories that attempt to explain the Torah by examining its subtexts. Modern women have taken a keen interest in this practice, hoping to expand on the minute biblical mentions of women like Dinah.  Ã‚  Ã‚  Ã‚  Ã‚   Form, structure and plot   Ã‚  Ã‚  Ã‚  Ã‚  The Red Tent is organized in a seemingly complicated yet beautifully simple way. There are three main sections; Dinah's mothers' story, her childhood, and her life in Egypt. Each is further divided into chapters.   Ã‚  Ã‚  Ã‚  Ã‚  Although the story is divided into sections, the plot progresses intact. The exposition consists of Jacob's arrival and subsequent marriages to Leah, Rachel, Zilpah and Bilhah. Twelve of thirteen children are born, including Dinah, narrator and only daughter. Dinah grows up helping her aunt/mother Rachel, who brings her to the city of Shechem. The initial incident occurs when Simon and Levi, two of Dinah's oldest brothers, enter the city of Shechem and murder all of the resident men, including Dinah's beloved husband, Shalem. Cursing her entire family, a pregnant Dinah is taken to Egypt by Shalem's mother, Re-nefer. In the rising action the child is born, a boy who Re-nefer names Re-mose and raises as her own. He becomes a superior Egyptian scribe, and is eventually assigned to the king's right-hand-man. In a climactic irony, Re-mose's employer turns out to be Joseph, Dinah's youngest brother. The truth about Shalem's murder is revealed to Re-mose, who in turn vows to avenge his father's death on Joseph's head. He is thwarted by Dinah, who convinces him to remove to the north. Joseph and Dinah attend the death of Jacob in the falling action, both forgiving the wrongs committed against them in their father's name. The story concludes with Dinah's death. Point of View   Ã‚  Ã‚  Ã‚  Ã‚  Diamant has Dinah effectively tell her story from three different narrative perspectives. The bulk of the novel is related by Dinah in first person, providing a private look at growing up and personal tragedy: "It seemed that I was the last person alive in the world" (Diamant 203). Dinah tells the story that she says was mangled in the bible. Understandably, Dinah's relation of her mothers' stories is done in third person narrative, since she herself was not yet born.

Isearch

Body To figure out the answer to my question I had to find people who have graduated room MOOSE. I went home and asked my mom and she said I have a cousin who attended MOOSE. Dave attended MOOSE thirty years ago. Dave also played for the baseball team and has a great Job of being a Senior Vice President at EMCEES Inc. In Milwaukee, Wisconsin. I figured Dave would be great to ask because of his liking for sports, and he and I are pretty similar in things we enjoy doing, so he would give good information coming from a perspective very similar to mine.The other person I e-mailed was Grant Ileum. I knew Brock Ileum's uncle was an engineer, but I didn't realize was that Grant owns his own business. Ileum Engineering makes ramps, risers, rail boards and engineered dock products. I also went online to an online discussion site and found some very interesting reviews from Jeff and Christopher on Capped. When I am wondering what I want in a college I think of price, campus quality, activities , and Job readiness. I asked questions and looked for answers based off of these four characteristics.I found that the answers vary substantially from person to person. Some support the school while others bash on MOOSE. I know he price at MOOSE is astonishing and very high. I have heard of great scholarships given out by MOOSE, but I don't know if everyone receives them. Based on the information I received most students get scholarships, but both Christopher and Dave said even with scholarships MOOSE did put a burden on their wallet. Everyone agreed that with the high price come the great professors, top notch learning materials, and also a laptop you get to keep after college.Dave said â€Å"There are a lot of businesses that invest heavily in MOOSE, so the school stays on the cutting edge with genealogy. † With businesses investing it helps cut down on the price while you still get the latest and greatest technology. Milwaukee can be dangerous, run-down, and deprived. I ne ed to know if the MOOSE campus is safe and clean enough for me. It is very assuring to hear that the campus is on a twenty four hour security schedule every day of the year. All of my sources say MOOSE is always trying to make the campus bigger and cleaner.Dave mentioned that the Kern Center are very neat and enjoyable to be in. Through my research I don't deed to have a car because of the small campus, and to get to the grocery store MOOSE provides buses to take students. The buses make going places a lot safer and makes the streets less clogged with the thick Milwaukee traffic. Being right in Milwaukee there has to be tons of activities to do. I knew MOOSE has many collegiate sports teams. The city of Milwaukee also hosts the Brewers and Bucks, but being a college student I probably won't be able to afford all that.Everyone I talked to was in at least one club and MOOSE encourages people to create new clubs as well. Dave was n intramural sports and it was where he met some of his closest friends. Jeff said â€Å"The lakefront is simply breathtaking and the museum is quite a sight to see. † Also there is fraternity parties that I may have to attend quite often. Once I graduate I need to be ready for my Job. I don't think I need to know about art history or music history to help me out with engineering. According to my sources MOOSE puts you into your major right away, which helps you get done in four years.MOOSE has a Job placement rate of ninety four percent, which is great, but do they prepare you engineer a product for them and, if you don't engineer something worthwhile you can't graduate. Also Dave said MOOSE doesn't teach theory they do practical applications which he feels fully prepared him for his great Job. Conclusion Now that I have researched about MOOSE many thoughts have gone through my head. To find the final answer first I have to answer the four characteristics I was researching. The price of MOOSE is very high, but most people get a s cholarship. I think MOOSE might be too expensive for me.The campus quality is amazing and I hint I get really enjoy living on the MOOSE campus. To have fun at college I want to participate in many activities. I think MOOSE has plenty of fun activities to do plus everything else in the Milwaukee area. When I graduate I want to be as prepared as possible and I believe MOOSE does a wonderful Job of that. Three of four categories is looking good, but I feel I want one that is four out of four. To answer my question, MOOSE is partially right for me. I will base more colleges of my criteria until I find one that is perfect, but if I don't MOOSE will always be high on my college list.

Changing the Target Audience in Retail Sales

â€Å"On average, middle-aged consumers devote 39 percent of their retail expenditure to department store products and services, while for younger consumers the average is only 25 percent. Since the number of middle-aged people will increase dramatically within the next decade, department stores can expect retail sales to increase significantly during that period. Furthermore, to take advantage of the trend, these stores should begin to replace some of those products intended to attract the younger consumer with products intended to attract the middle-aged consumer. Essay 1: The argument that department retail sales will increase in the next 10 years and thus department stores should begin to replace products to attract middle-aged consumers is not entirely logically convincing, since it omits certain crucial assumptions First of all, the argument ignores the absolute amount of retail expenditure of middle-aged and younger consumers devoted to department store products and services. Although younger consumers spend a smaller percentage of their retail expenditure to department store products than do the middle-aged consumers, they might actually spend more in terms of the absolute amount. Even if middle-aged consumers are spending more than younger ones in department stores, the argument ignores the possibility that the trend may change within the next decade. Younger consumers might prefer to shop in department stores than in other types of stores, and middle-aged consumers might turn to other types of stores, too. This will lead to a higher expenditure of younger consumers in department stores than that of middle-aged consumers. Besides, the argument never addresses the population difference between middle-aged consumers and younger ones. Suppose there are more younger consumers than the middle-aged ones now, the total population base of younger consumers will be bigger than that of the middle-aged ones if both of them grow at the same rate in the next decade. Thus there will be a bigger younger consumer base. Based on the reasons I listed above, the argument is not completely sound. The evidence in support of the conclusion does little to prove the conclusion since it does not address the assumptions I have already raised. Ultimately, the argument might have been more convincing by making it clear that the absolute population of middle-aged consumers are higher than that of the younger consumers and the number will continue to grow in the next decade, and that the middle-aged consumers will continue to spend more money in department stores than younger consumers do in the next decade. Essay 2: The argument that retailers should replace some of the products intended to attract the younger consumers with products intended to attract the middle-aged consumers is not entirely logically convincing, since it ignores certain crucial assumptions. First, the argument omits the assumption that the business volumes of both the middle-aged consumers and the younger consumers are the same. If the business volume of the middle-aged consumers’ 39% is smaller than that of the younger consumers’ 25%, the retail sales will not increase during the next decade. Second, even if the business volumes of both the middle-aged consumers and the younger consumers were the same in the last decade, the increase of the middle-aged people in the next decade is not the same as the increase of the retail expenditure, for the retail trade depends more on such factors as the economic circumstances, people’s consuming desire. Finally, the argument never assumes the increase of the younger consumers within the next decade. If the younger consumers increase at the same rate and spend the same amount of money on the goods and services of department stores, the retailers should never ignore them. Thus the argument is not completely sound. The evidence in support of the conclusion that the growing number of middle-aged people within the next decade does little to prove the conclusion—that department stores should begin to replace some of their products to attract the middle-aged consumers since it does not address the assumptions I have already raised. Ultimately, the argument might have been strengthened by making it clear that the business volumes of both types of consumers are the same and comparable, that the increase of a certain type of consumers are correlated with the increase of the retail sales, and that the growth rate of the younger consumers are the same as that of the middle-aged consumers. Essay 3: Based on an expected increase in the number of middle-aged people during the next decade, the author predicts that retail sales at department stores will increase significantly over the next ten years. To bolster this prediction, the author cites statistics showing that middle-aged people devote a much higher percentage of their retail expenditure to department-store services and products than younger consumers do. Since the number of middle-aged consumers is on the rise and since they spend more than younger people on department-store goods and services, the author further recommends that department stores begin to adjust their inventories to capitalize on this trend. Specifically, it is recommended that department stores increase their inventory of products aimed at middle-aged consumers and decrease their inventory of products aimed at younger consumers. This argument is problematic for two reasons. First, an increase in the number of middle-aged people does not necessarily portend an overall increase in department-store sales. It does so only on the assumption that other population groups will remain relatively constant. For example, if the expected increase in the number of middle-aged people is offset by an equally significant decrease in the number of younger people, there will be little or no net gain in sales. Second, in recommending that department stores replace products intended to attract younger consumers with products more suitable to middle-aged consumers, the author assumes that the number of younger consumers will not also increase. Since a sizable increase in the population of younger consumers could conceivably offset the difference in the retail expenditure patterns of younger and middle-aged consumers, it would be unwise to make the recommended inventory adjustment lacking evidence to support this assumption. In conclusion, this argument is unacceptable. To strengthen the argument the author would have to provide evidence that the population of younger consumers will remain relatively constant over the next decade.

Charismatic leadership

Hence, most studies were done to seek to explain what leadership is and to identify the characteristic of the people who are successful in its leadership practice. Various leadership theories came out. Kurt Lenin identified leadership styles in three categories: Autocratic Leadership, Democratic Leadership and Delegating Leadership (Lippies, 1939). Max Weber classifies leaders as Bureaucratic Leader, Traditional Leaders and Charismatic Leaders. In 1978 Burns defined yet another classification: Transactional Leaders and Transformational Leaders. Burns Transformational Leadership Is similar to Charismatic Leadership style proposed by Weber.Many of the research have been done on various aspects of charismatic leadership. In this essay I would Like to give an overview of leadership and focus on charismatic leadership. In addition, I will identify Steve Jobs as a charismatic leader and explain his charismatic leadership with examples. 2. Definition of â€Å"Leadership† Leadership i s something very crucial to any group or organization. What a leader does Is usually very difficult to describe In words. John Martin defined leadership as a process In which the leader Is able to Influence the behaviors and actions of those eyeing led (Martin, 2005).While Keith Grant simply described leadership as â€Å"having followers†. Most of the definition is close to that of power, drawn from Webber and Dahlia's original idea that power (and thus leadership) was the ability to get someone to do something they wouldn't otherwise have done (Grant, 2010). Many are based on autobiographical or biographical accounts-relate leadership to the person regarded as leader. Others define leadership as a process-this may be the style that leaders adopt, or a process such as sense-making, or the practices of leaders.Some define dervish by simply considering what those in authority do-a positional approach. This approach tends to lock leadership into monopolizing a group or community to achieve a purpose-a result approach. Leadership vs.. Management The terms management and leadership are frequently used Interchangeably. But are they really the same? What are the differences between these two terms and what similarities they have In common? Both of leadership and management Involve groups of people and specific functions in relation to the group and its activities. It unless the group was in a specific context.An informal, friendship or trade union rope would not usually be described as having a manager, but there would inevitably be a formal or informal leader of such groups. A department would, however, have a manager as the formal leader of that particular group. The two terms therefore have aspects in common, but are synonymous only up to point. Leaders are said to be the ones with vision who are capable of getting the best performance out of their team, whereas managers are the ones who by concentrating on organizing, planning and controlling activity (Mar tin, 2005).Management What It Is complexity. Clear Job definitions. What It Produces†¦ Deals with Seeks to create order and discipline. Authority commensurate with responsibility Is all about doing things right. Careful integration of plans and effort. An emphasis on formal structures and systems. Leadership Flexible Job definitions. Deals with change. Seeks to create new approaches, breaks with the normal, stimulates innovation. Constant adaptation and accommodation to shifts in roles. Is more about doing the right things. Reliance on open dialogue and mutual trust to resolve conflicts. An emphasis on informal networks. Table 1 The difference between management and leadership Source: Stringer (2002) As far as I am concerned, leadership is setting a new vision or direction for a group while management commands or directs a group according to principles or targets that already existed before. Leadership and management are complementary and necessarily linked. Both of them are ve ry important in the organizations.As the world has come to the knowledge era, where value comes increasingly from the knowledge of people, management now is not Just to assign tasks but also to define purpose. 3. Charismatic Theory Charisma is a â€Å"divinely bestowed power or talent† and its etymological origins lie in he Greek word Charisma, from Sharks: â€Å"divine grace† or â€Å"favor† (Grant, 2010). Weber defined the term charisma as â€Å"certain quality of an individual personality, by virtue of which he is set apart from ordinary men and treated as endowed with supernatural, superhuman, or at least specifically exceptional powers or qualities. House (1977) characterized charismatic leaders as full of self-confidence, with a high level of confidence in subordinates and high expectations for results. They also have a clear vision of the goal to be achieved, are able to communicate this effectively and lead by example. Charismatic leaders are with excep tional qualities which made them almost god-like for their followers. They inspire followers to transcend their own self-interest for the good of the organization and are capable of having a profound and extraordinary effect on his or her followers (Robbins, 2005).Franklin D. Roosevelt, Margaret Thatcher, Jesse Jackson, Bill Clinton, Steve Jobs are the examples of charismatic leaders. After having described what is charisma and charismatic the attributes that charismatic leaders possess or what are the traits which make someone a potential charismatic leader? According to charismatic leadership theory, lowers make attributions of heroic or extraordinary leadership abilities when they observe certain behaviors (Conger & Kananga, 1988).After studying on this issue for a long period of time, Conger and Kananga (1998) then described five behavioral attributes of Charismatic Leaders- they have a vision, are willing to take risks to achieve that vision, are sensitive to both environmental constraints and follower needs, and exhibit behaviors that are out of the ordinary-that differentiate charismatic leaders from uncharismatic ones. Vision and articulation Has a vision-expressed as an idealized goal-that proposes a future better than the tutus quo; and is able to clarify the importance of the vision in terms that are understandable to others (Conger & Kananga, 1988).Vision is the key characteristic of charismatic leaders. They offer a vision (or lofty goal) of where the organization is headed and how it can get there (plan) (Dublin & Young, 2007). A sense of vision inspires employees to perform well. It encourages people to work, to strive for its attainment. For example, the vision set by Bill Gates for Microsoft is â€Å"Empower people through great software, anyplace, any time and on any device†. Personal risk Willing to take on high personal risk, incur high costs, and engage in self-sacrifice to achieve the vision (Conger & Kananga, 1988).A leader that i sn't willing to step outside his/her comfort zone is losing out on the most important aspect of leading. They need to be willing to push the envelope in every direction. Sometimes, leaders need to break new ground that no one has done before and so there are always risks involved. Leaders who are unwilling to take risks will become stagnant with no ability to innovate or change. Environmental sensitivity Able to make realistic assessments of the environmental constraints and resources added to bring about change (Conger & Kananga, 1988). Realistic about the constraints imposed upon them.They know what they can and cannot do. This sensitivity to both social economic, cultural and political environment enables them to quickly identify and recognize the barriers, hindrances, and opportunities that affect the organization or people (Conger & Kananga, 1992). Leadership that is highly sensitive to the environment is quite entrepreneurial because it readily recognizes and exploits new oppo rtunities in the environment such as social and physical conditions that may facilitate the achievement of organizational objectives (Conger Kananga, 1992).Sensitivity to follower needs Perceptive of other's abilities and responsive to their needs and feelings (Conger & Kananga, 1988). Charismatic leaders are sensitive to member output which is a result of motivation. Motivation results from satisfying member needs and it is as a measure of the extent of a leader's influence (House, 1995). These outcomes will result in Job satisfaction and reduce dissatisfaction include high Job output and organizational performance. Examples of this attribute include being open and receptive to complaints and new ideas, sensitivity to personal and develop follower's rationality and improve their welfare.Unconventional behavior Engages in behaviors that are perceived as novel and counter to norms (Conger & Kananga, 1988). Their ways, when successful, elicit admiration. An example would be everything into a game where having fun is on top of his agenda. So he enjoys mixing work with pleasure and has successfully created an easy-going and fun-loving culture at Virgin. 4. Application of the theory to Steve Jobs Steven Paul â€Å"Steve† Jobs was an American entrepreneur, marketer, and inventor, who was the co-founder, chairman, and CEO of Apple Inc.He was widely recognized as a harmonistic leader and a pioneer of the personal computer revolution and for his influential career in the computer and consumer electronics fields, transforming one industry after another, from computers and smoothness to music and movies. â€Å"There's something going on here, something that is changing the world. And this is the epicenter. † Said Steve Jobs during his initial Apple Computers start-up. A ‘visionary' is how he is most often described. He is considered by many to be the number one visionary of Silicon Valley. One of his visions is to make Paxar Animation as successful as Disney studios.His earlier visions for Apple Computer may have changed personal computing. Jobs was among the first to see the commercial potential of Xerox Para's mouse-driven graphical user interface, which led to the creation of Macintosh. He also played a role in introducing the Illustrates, one of the first widely available laser printers, to the market. He is not only able to dream big visions, but also can articulate it. â€Å"Innovation distinguishes between a leader and a follower†, said Jobs. The very nature of innovation requires a departure from the status quo and deviation from the norm.The best leaders are risk takers who understand that fact and the tenacity to lead an organization to that future state despite organizational inertia and resistance. It is because his willing to take on risk, Jobs has transformed seven industries and belongs in the pantheon of America's great innovators, along with Thomas Edison, Henry Ford, and Walt Disney In 1985, Jobs got fir ed from Apple. During this time, Jobs were still looking for opportunities and took on new challenges. He bought Paxar, transforming it from a tiny animation house to an industry leader. He also started up computing firm NeXT which was later bought by Apple.Jobs is a charismatic leader who is able to make realistic assessments of the environmental constraints and resources needed to bring about change. â€Å"So when a good idea comes, part of my Job is to move it around, Just see what different people think, get people talking about it, argue with people about it, get ideas moving among that group of 100 people, get different people together to explore different aspects of it quietly, and?Just explore things†. Jobs enjoys working with people who are competent, smart, and â€Å"loved† Apple. He also exchanged ideas with them, and had inspired many of them.Steve Jobs is a good leader who is sensitive to his follower's needs. The Company's success, high employee retention and consistent recognition as one of â€Å"best places to work† are proof of this. Steve Jobs was an unconventional leader. He wasn't known for his consultative approach. He demanded excellence from his staff and was known for his impatience, tough with work with only the best. Despite all these, Steve Jobs still remained popular among his co-workers. And during his battle against his final illness, Jobs was surrounded by an intensely loyal cadre of colleagues. Steve Jobs is a charismatic business leader.His personal traits are characteristics of charismatic leaders: he is a man of vision and a risk taker to achieve that vision. He is sensitivity to follower needs, perceptive of others' abilities and responsive to their needs and feelings and has demonstrated unconventional behavior, engages in behaviors that are perceived as novel and counter to norms. 5. Conclusion This essay explains enough information about the charismatic leadership. There are some questions about the c harismatic leadership which have still remained unanswered. After describing the attributes of the charismatic leader and identifyingSteve Jobs as one example, it remains unknown that what makes a charismatic leader a â€Å"hero† and what makes him a â€Å"villain†. Are there any specific attributes that make charismatic leader as a â€Å"hero† or a Milan†? The second question is regarding the â€Å"making of charismatic leaders†. After establishing that the charismatic leaders have certain characteristics, it remains to see that if everyone having those attributes can become a successful leader. And this question gives rise to yet another question that whether a charismatic leader can be â€Å"made†. Is it possible to â€Å"create† charismatic leaders by formal education?